Rapid progress of infrared focal plane array (IRFPA) technology needs better nonuniformity correction (NUC) methods. However,the prevailing twopoint or multipoint correction algorithms based on calibration methods can′t effectively overcome the nonlinearity and spatiotemporal drift of the detector response parameters. A novel combined realtime nonuniformity correction method based on field programmable gate array (FPGA) technology is presented in this paper. The method adopts the binomial fitting algorithm based on calibration to remove the main nonuniformity of the detector,and the remained nonuniformity is compensated by using the scenebased temporal highpass filter algorithm. The block diagram of hardware circuit and the processing flow are described in details. The experiment results show that the combined method can access the ideal efforts and may satisfy the requirements of the future IRFPA applications.