Based on the conventional MI approach,we propose a new registration method with the combination of intensity and spatial information.It includes two stages,one is coarse registration with spatial information of image,and the other is fine registration with ACMI.This spatial information is normalized gradient vector information (NGVFI) instead of ordinary gradient information,and it can enhance the noise resistibility greatly during coarse registration.The experimental results show that our method is very effective and robust,and the registration accuracy reaches sub-pixel successfully.