A method for image fusion based on multi-orientation gradient mode is proposed.Source image is divided into some image sub-blocks.Multi-orientation gradient filters are constructed by directional derivative.Image blocks are filtered by the multi-orientation gradient operators for extracting characters of edge on different orientations.Compared with the total value of the gradient of image block for judging the pixel is focused or not,then generate fused image.Experiments illustrate this method is simplified and availability and show that the method for multi-focus image fusion has good results and good stability.