This paper presents a simulation method of building 3D infrared scene.Firstly,analyzes the method of 3D scene model,which gains 3D scene by software drawing and loads it into OpenGL environment for further disposing.Secondly,analyzes the method of 3D infrared scene,which simulates the radiant point,builds infrared imaging model and obtains the infrared radiation characteristic of building surface.Finally,produces building infrared 3D scene by simulating infrared thermal instrument.It can be seen from the experiment results that simulation images truly reflect the infrared characteristics of building target and the change law between simulation temperature and measuring temperature is basically consistent.The simulation method is practical and feasible,which has reached the effect of scene simulation.