According to the characteristic of 288×4 LWIRCMOS Integrated Detector Dewar Cooler Assembly named PLUTON LW K508,a drive module is designed to provide the Detector Assembly with clock,control signals,analog power,digital power,reference level and control signals of refrigeration mode,etc.The design principle and configuration of three key circuits:power on circuit,bias voltage GPOL generation circuit and refrigeration mode control circuit are described detailedly.Experimental results show that the collected infrared images have the characteristic of low noise,high precision,and high stability.The average noise voltage of the images acquired by the whole infrared image collecting system is below 0.4 mV when the detector is radiated by the 293 K to 353 K blackbody with an integral time of 19 μs.