The article analyzes the non-uniformity of scanning infrared camera,constructs corresponding non-uniformity mathematical model,offers a scene-based non-uniformity correction method and implement it by programming on DSP.The method combines movement estimation with recursion least two multiplication to implement real-time space non-uniformity correction.It also combines neural network with least-mean-square to implement real-time compensation of non-linear non-uniformity after two-point correction.The practical results show that the algorithm is valuable in engineering application.