Because photoelastic modulator requires the drive circuit of high Q value, high voltage and high stability, a high voltage drive circuit based on LC resonant boost principle is designed. The circuit is mainly composed of the input waveform converting circuit, power amplifier circuit, charge and discharge circuit, impedance matching circuit and feedback signal acquisition circuit. A high quality factor inductance is made by low permeability core. The output voltage of the circuit is higher，while the DC power supply voltage requirements is lower. The experiments show that：at the resonant frequency 50.04 kHz of photoelastic modulator, the adjustable output voltage of the circuit is 0 to 1200VP-P, the maximum supply voltage of input DC power is 29 V. This circuit has a strong load capacity and can fully meet the demand to drive the photoelastic modulator crystal.