To achieve the seal of the high-pressure gas in the device,a set of laser welding processing equipment was designed and manufactured.The effect of laser processing parameters on the welding process was studied,and the influences of some parameters such as pulse energy,defocusing amount,helium pressure on weld depth,weld appearance and tightness were analyzed.The results show that the 10 MPa helium sealed in the devices and leakage rate of less than 1.33×10-9 Pa·m3/s were achieved by optimizing the process parameters.In addition,with the increase of helium pressure,the weld depth increases gradually,weld appearance has been improved and the metal luster of weld surface has been enhanced.