To evaluate the jamming effect of laser angle deception,the hardware-in-the-loop simulation (HILS) system of laser angle deception is set up. The simulation system introduced some real equipments,such as laser seeker,IMU,missile-borne computer,steering engine,and so on. Then the key techniques were adopted to real-time ability and reliability of the system,including real-time communication,attitude angle precision simulation,angle of sight precision control,multithread trigger,acceleration simulation injection,etc. Taking a typical laser guidance weapon as the object of jamming,the simulation research was carried out. Under the given condition,miss distance is 1.7 m when there is no interference,but the miss distance is 744.05 m when the interference exists. The results show that the system can evaluate the jamming effects of laser angle deception effectively,and the reasonableness of guidance and control system and hardware and software of HILS system are verified.