Photoelectric guidance weapon greatly threatens the target’s survival in battlefield.However,smoke screen is an effective jamming means to photoelectric guidance weapon.Through analyzing the working principle of smoke screen on visible light and infrared radiation,a interference platform of smoke screen is established and the interference data of smoke screen on infrared imaging guidance and scene matching guidance systems are obtained.The results show that the smoke screen can effectively decrease the operation distance and target identification capacity of infrared imaging guidance system,and can severely weaken the performance of scene matching guidance algorithm,even can cause the algorithm’s complete failure.