Establishing analytical relationship between process parameters and laser cladding profiles is the premise to understand complex laser-powder coupling mechanism and it is also the basis for technique implementation and single-track profile control and prediction.The influences of laser power,scanning speed,gas flow rate,and depth of defocus on three response values (clad width,clad height and cross-sectional area) of cladding layer were studied by response surface method (RSM).The influence of laser-powder coupling on forming of laser claddings is also investigated.The results show that three responses increase with the increase of laser power and the decrease of scanning speed; three responses decrease with the increase of gas flow rate; Depth of defocus has no obvious effect on clad width,but clad height and cross sectional area decrease with the increase of depth of defocus. Then,mathematical models between influence factors and three responding values were built.The adjusted R-Squares are 0.7321，0.8749 and 0.9137,respectively,and the predicted R-Squares are 0.6371,0.8007 and 0.8630 for three response models,respectively,which matches the test data well.Finally,the experiments prove that the errors of three models between predicted values and experimental values was less than 5%,which indicate the reliability of the regression model.