Infrared imaging is often disturbed by stripe non-uniformity noise,while scene-based correction method can effectively reduce the influence of stripe noise.A stripe non-uniformity correction method based on differential constraint is proposed.Firstly,the gray distribution of stripe non-uniformity is analyzed and the penalty function is constructed by the difference of horizontal gradient and vertical gradient.By introducing the weight function,the penalty function is optimized to obtain the corrected image.Compared with other methods,experiments on real scenes show that the proposed method performs better in both subjective and objective analysis,and has less damage to image’s edge and detail.Meanwhile,the proposed method runs faster,and it is well applied in hardware.