Mid-infrared random laser based on Fe2+ doped ZnSe powders embedded in ZBLAN glass with a center wavelength at ~4.32 μm is developed at room temperature.The average grain size of micro-sized Fe2+:ZnSe powder is 3.54 μm,and the XRD results indicated that the micro-sized Fe2+:ZnSe powders are of cubic zinc blende structure.The threshold of the random laser is 557.89 mJ/cm2 under the 2.94 μm nanosecond pulse laser.The characteristic of the multi-longitudinal mode of random laser appears with the increasing of pump energy.As the pump energy increases until it exceeds the threshold,the random laser has a narrow spectral line-width of 10 nm,and the steady pulse width drops to 50 ns.This work provides a simple and cost-effective way to obtain stable mid-IR laser source.Embedding powders into solid host can be an appropriate method to stabilize powders,especially for middle-infrared lasing powders,which have the potential use for fabricating middle-infrared photonic devices and fiber laser.