The GPS-based infrared imaging direction finding cross-location research is carried out.GPS technology is used to locate the stations and determine the reference of direction-finding.The geographic projection coordinate system is used for location.The mathematical models of dual-station cross-location,station location and direction-finding are built.The relationship between location error and system configuration including station location,GPS positioning accuracy and angle measurement accuracy is studied.The simulation experiment method based on SolidWorks is proposed to verify the correctness of the mathematical model of dual-station cross-location.Two groups of field experiment are designed,which have fully verified the effectiveness of the proposed method.Experimental results show that the location error is less than 0.5 m for the target 1 km away.The proposed method does not require the stations to be visible to each other,and it is convenient to describe the geographical azimuth that target deviate from the station or any other position with GPS known.It shows important application value in many fields.